WCPCW XXI Mar 17-20, 2013

Schedule WCPCW XXI

Program Schedule

Sunday March 17th, 2013

5:30pm Registration - Cypress Foyer

7:00pm Opening Comments - John Williams, Beckman Research Institute

7:10-8:15pm KEYNOTE
Wayne Hendrickson
University Professor, Columbia University
Anomalous Diffraction Analysis of Native Biological Macromolecules

Session 1 - Vendors
Discussion Leader: John Williams


Joby Jenkins, TTP LabTech
"Automated protein crystal optimization with TTP LabTech’s dragonfly"


Matthew Benning, Bruker AXS Inc.
"Revolution without Rotation: Experiences with a Liquid Metal X-Ray Source"


Christopher Bonagura, Art Robbins Instruments
"The Scorpion"


Jian Xu, Rigaku Automation, Inc.
"Practical Applications towards Maximizing Effectiveness and Efficiency of a Crystallization Screen Maker for Optimization"


Claes Gustaffsson, DNA2.0
"Using Infologs for multidimensional gene and protein optimization"


Matthew Ford, Agilent Technologies, Inc
"Collecting X-Ray Data in the Home Lab: Agilent Structural Biology Solutions"

9:30-11:30pm Social

Monday March 18th, 2013

8:00am Continental Breakfast – Lower Terrace (weather permitting)

Session 2: Methods 1
Discussion Leader: Jim Holton


Andy Karplus, Oregon State University
"Better refined models derive from including high-resolution data beyond conventional limits"


Ana González, Stanford Synchrotron Radiation Lightsource
"Advanced Automation at SSRL with AutoDrug"


Tzanko Doukov, Stanford Synchrotron Radiation Lightsource
"Sulfur Phasing Structure Determination at SSRL’s BL12-2"


Robert Thorne, Cornell University
"Preparing for a Warmer Future: Radiation Damage to Protein Crystals at Ultra-High Dose Rates"

10:00am Coffee Break – Foyer of Cypress Ballroom

Session 3: Membrane and Channel Proteins
Discussion Leader: Celia Goulding


Nilou Ataie, University of Hawaii
"Identification of Optimal Membrane Protein Candidates for X-Ray Crystallography"


Robert Stroud, University of California, San Francisco
Methods for the structures of eukaryotic membrane protein structures


Hartmut Luecke, University of California, Irvine
"Structure, function, and inhibitors of the acid-gated Helicobacter pylori urea channel, an essential component for acid survival"


Alex J. Vecchio, University of California, San Francisco
"Progress towards 3D structures of claudins"


Jonas Lee, California Institute of Technology
"Crystallization and structure determination of bacterial ABC transporter Atm1p homolog by combining four individually ineffective detergents"

12:00pm Lunch - Upper Plaza (Weather Permitting)

1:00pm-6:00pm Free time

6:00pm Dinner – Dolphins Room (Upper Plaza)

Session 4 Immune System
Discussion Leader: Seth Rubin


Krzysztof Bzymek, Beckman Research Institute, City of Hope
"From mimotope to meditope - discovery of a novel antibody-peptide binding interface and its potential applications"


Markus-Frederik Bohn, University of Minnesota Medical School
"Crystal structure of the catalytic domain of APOBEC3F suggests an HIV-1 Vif interaction and dynamic oligomerization"


Ivana Nemcovicova, La Jolla Institute for Allergy and Immunology
"Structure of Human Cytomegalovirus UL141 Binding to TRAIL-R2 Reveals Novel, Non-canonical Death Receptor Interactions"


Alysia Birkholz, La Jolla Institute for Allergy and Immunology
Novel NKT Th1-Skewing Glycosphingolipid Antigens

8:30pm Refreshment Break

Session 5 Proteins
Discussion Chair: Hartmut Luecke


Justin Biel, Oregon State University,
"Bent out of Shape: All Prolyl Peptides deviate from Planarity"


Byron DeLaBarre, Agios Pharmaceuticals,
"Adventures in Allostery"


Rodrigo Torres, University of California, Irvine
"Structural insights suggest conformational change s important for the function of Yersinia pestis RipA, a butyryl CoA transferase"


Yarrow Madrona, University of California, Irvine
P450cin Water: Effects on Substrate Binding and Solvent Accessibility

10:00pm-12:00am Poster Session - Social

Tuesday March 19th, 2013

7:45am Continental Breakfast – Lower Terrace (weather permitting)

Session 6 – Methods 2
Discussion Leader: P. Andrew Karplus


Dale Tronrud, Oregon State University
"The Construction of Conformation-Dependent Ideal Geometry Libraries when the Available Sample Size is Small"


James Holton, University of California, San Francisco
"Why don’t my crystals diffract?"


Nathaniel Echols, Lawrence Berkeley National Laboratory
"Improved protein crystal structures at low resolution by integrated refinement with Phenix and Rosetta"


Piotrek Sliz, Harvard Medical School,
"Molecular Replacement: Range of Convergence for protein and nucleic acid structures"


Pavel Afonine, Lawrence Berkeley National Laboratory
"Advances to address low-resolution refinement challenges in Phenix"

10:10am Coffee Break – Foyer of Cypress Ballroom

Session 7 - DNA/RNA Proteins
Discussion Leader: John Tainer


Seth Rubin, University of California, Santa Cruz
"Cks Confers Specificity to Cyclin Dependent Kinase Signaling Pathways"


David Kemble, University of Utah
"Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT"


Nicole Schirle, The Scripps Research Institute
"The Crystal Structure of Human Argonaute2"


Ursula Schulze-Gahmen, University of California, Berkeley
"The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat"


Renzo Corzano, Beckman Research Institute, City of Hope
"Targeting the Achilles Heel of Stat3"

12:05pm Lunch - Upper Plaza (Weather Permitting)

1:00pm Free time

6:00pm Dinner – Dolphins Room (Upper Plaza)

Session 8 - Structure-Function
Session Chair: Rebekka Wachter


Grace Festin, University of California, Irvine
"Unraveling the Mystery of Di-domain ARO/CYCs Through StfQ and BexL


Nicole Wheatley, University of California, Los Angeles
"Bacterial Microcompartment Shells of Diverse Functional Types Possess Pentameric Vertex Proteins"


Geoffrey Feld, Lawrence Livermore National Laboratory
"Structural-functional genomics approach reveals function of novel virulence factors from Francisella tularensis"


Robert Morse, University of California, Irvine
"Structural and Functional Insights into Bacterial Contact-dependent Growth Inhibition"

8:30pm Refreshment Break

Session 9 - Structure-Function
Session Chair: Piotrek Sliz


Jeffrey Holden, University of California, Irvine
"Promoting Bacterial Stress by Inhibiting a Bacterial Nitric Oxide Synthase"


Nathan Henderson, Arizona State University
"Structure and Assembly of Rubisco Activase from Higher Plants"


Camden Driggers, Oregon State University
"Cystein Dioxygenase from pH 4 to 9: consistent Cys-persulfenate formation and views of the unliganded and Cys-bound enzyme"


Ho Jun Lee, University of California, Berkeley
"Cyclic-AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis"


Christine N. Morrison, California Institute of Technology
" Crystal Structure of the Nitrogenase MoFe Protein from Clostridium pasteurianum at 1.12 Å"

10:00pm-12:00am - Poster Session - Social

Wednesday March 20th, 2013

7:45am Continental Breakfast – Lower Terrace (weather permitting)

Session 10 Methods 3
Discussion Leader: Chris Hill


Peter Zwart, Lawrence Berkeley National Laboratory
"Fluctuation Scattering: SAXS at the femtosecond timescale"


James Holton, University of California, San Francisco
"The Structure of Disorder"


Greg Hura, University of California, Santa Cruz
"Connecting Structure with Biology by Combining SAXS and Crystallography"


Johan Hattne, Lawrence Berkeley National Laboratory
"Using an XFEL to elucidate the water-oxidation mechanism of PS II"

9:50am Coffee Break – Foyer of Cypress Ballroom

Session 11- Structure Function/Design
Discussion Leader: Tom Poulos


Ryan VanderLinden, University of Utah
"Structure and Energetics of Rpn13-Ubiquitin Interactions"


Arden Perkins, Oregon State University,
"Two dramatically different conformations in a single crystal environment: Insights into the thermodynamics of the peroxiredoxin active site."


Debasish Chattopadhyay, University of Alabama at Birmingham
"Poxvirus Uracil DNA Glycosylase: A Comprehensive Analysis of an Unusual Processivity Factor"


Cindy Zer Beckman Research Institute, City of Hope
"Structure-based design of Meditope-enabled mAbs"


Jawahar Sudhamsu Genentech
"Structure of the BRAF:MEK1 complex − How different BRAF inhibitors may have distinct effects on cell fate depending on the conformation they induce"


Yen-Ting Lai, UCLA
"Crystal Structures and Flexibility of Designed Protein Nanocages"

11:45am-12pm Closing Remarks – Presentation/Poster Awards

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